The Effectiveness of an Online Decision Aid on Reproductive Options for Couples at Risk of Transmitting a Genetic Disease to their Offspring: Protocol for a Randomized Controlled Trial

Introduction: Couples at high risk of transmitting a genetic disease to their offspring have several reproductive options. As decision making is often experienced as difficult, there need for aid (DA), assist couples in decision-making process and reduce decisional conflict increase (joint) informed decision-making. This article describes the design nationwide randomized controlled trial assess efficacy online DA.Methods: The development DA was based on International Patient Decision Aid Standards (IPDAS) guidelines. A multi-centre Randomized Controlled Trial (RCT) will be conducted eight centres Netherlands effects DA, compared website with standardized information provided during standard care. required sample size 128 couples. Participants are randomly assigned either intervention or control group asked complete four questionnaires within six months study information. conflict, knowledge, attitude, deliberation, between partners.Discussion: Findings this can help improve counselling offspring. Additionally, it provides insight into joint could professionals better support both partners consultations.Trial registration number: N9415.